Both of these chemicals have been shown to make the body more effective at burning calories, which may lead to weight loss. In a study found that green tea catechin reduces belly fat in obese adults. Green tea has been found to help control blood sugar in the body because it helps break down carbohydrates. Especially with a diet high in fat and cholesterol, fat can begin to build up in the bloodstream. This causes veins and arteries to become enflamed, which leads to high blood pressure.
Green tea extract can decrease inflammation and inhibit fat absorption in cells. All blood sample analysis took place at the Second Affiliated Hospital in Kunming. Statistical analysis of the experimental data was performed using SPSS These results indicated that administration of EGCG could reduce obesity and the accumulation of epididymal fat in mice.
EGCG reduced obesity and the adipose weight in mice. A The body weights of mice after 20 weeks feeding; B Lee index; C ratio of subcutaneous fat weight to body weight; and D epididymal fat weight to body weight.
EGCG has previously been shown to increase fecal lipid content, suggesting decreased digestion and absorption of lipids Bose et al. Effect of EGCG on lipid excretion.
To explore the mechanisms by which EGCG reduced adipose indices in HFD mice, we separately determined the mRNA expression levels of genes associated with lipid metabolism in subcutaneous adipose tissue and epididymal adipose tissue. In subcutaneous adipose tissues, the expression of several genes for lipid synthesis, such as acc1 and fas , decreased significantly in the HFD group; however, EGCG administration increased their expression significantly by comparison Figures 4A,B , 6A.
Effect of EGCG on the expression of genes involved in lipogenesis, oxidation, and transportation in subcutaneous adipose tissues of mice. The relative mRNA expression of the hsl gene, which is involved in lipolysis, was decreased significantly in HFD and EGCG mice Figure 5G ; however, the expression level of another gene associated with lipolysis, atgl , was similar among all the groups Figure 5H.
Effect of EGCG on the expression of genes involved in lipogenesis, oxidation, and transportation in epididymal adipose tissues of mice. Therefore, we determined the activity of AMPK.
The objective of the present study was to determine whether the fat-loss functions of EGCG involved similar effects on regulation of lipid accumulation in different adipose depots, as well as to explore the underlying mechanisms. These results seemed contradictory in this study. The reason might be that our experiment had lasted for 20 weeks, some mice had higher body lengths along with higher body weights but not obese, which might have some effects on data analysis.
Then we calculate the fat index of mice, and found that EGCG significantly reduced fat accumulation in epididymal fat tissues, but not in subcutaneous fat tissues. These results indicate that EGCG reduce obesity might mainly via reducing lipid accumulation in epididymal fat tissue. Our results were partially consistent to previous studies of Lee et al. The reason might be that the doses of EGCG were different between our study and previous studies. A combined transcriptomics and lipidomics analysis on different adipose tissues demonstrated that gene regulation in response to HFD and fatty acid patterns differed markedly between adipose depots Caesar et al.
A previous study by Caesar et al. To explore whether EGCG had different effects on fat accumulation in subcutaneous and epididymal adipose tissues, we detected the expression of genes involved in the synthesis of de novo fatty acids and oxidization of fatty acids.
These results show that de novo lipogenesis was stably reversed by EGCG, whereas EGCG highly enhanced the mRNA level of delta-9 desaturase, which converts saturated fatty acids to monounsaturated fatty acids.
It also appeared that fatty acid synthesis and desaturation were not co-regulated under the control of EGCG in subcutaneous adipose tissues. Our results suggest that EGCG might have different roles in lipogenesis in subcutaneous and epididymal adipose tissues. Therefore, EGCG might act via different mechanisms in subcutaneous and epididymal tissues, owing to the different gene regulation of these tissues in response to HFD. Therefore, we examined the activity of AMPK in subcutaneous and epididymal adipose tissues.
These results indicated that expression of the lipogenic genes was not regulated by activation of AMPK. Therefore, our results suggest that there may exist other regulatory mechanisms of EGCG in adipose tissues; this requires further studies for clarification. These results were partially consistent with a previous report by Murase et al.
Gene expression analysis of lipid metabolism indicated that EGCG exerted its effects via different mechanisms in subcutaneous and epididymal tissues, owing to their different gene regulation in response to HFD. Furthermore, AMPK appeared to have a minor role in the regulation of genes involved in the processes of adipogenesis, lipogenesis, and lipolysis in both subcutaneous and epididymal adipose tissues. MZ helped in the animal experiments and some data analysis.
XiW wrote the manuscript. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Baladia, E. Effect of green tea or green tea extract consumption on body weight and body composition; systematic review and meta-analysis. Basen-Engquist, K. Obesity and cancer risk: recent review and evidence. Bernardis, L. Correlation between Lee index and carcass fat content in weanling and adult female rats with hypothalamic lesions.
Bolton-Smith, C. Dietary composition and fat to sugar ratios in relation to obesity. Google Scholar. Bose, M. Having the right mood can help you take the steps you need to overcome weight issues. It improves your cardiovascular system. With more energy, exercise will feel like fun rather than work. While researchers have been studying the potential health benefits and the various effects of EGCG for a few decades, this compound has continuously shown varied effects on human research subjects.
Scientists believe this inconsistency may be caused by the tendency of the compound to degrade when exposed to oxygen, which leads to an ever-changing amount that actually reaches the digestive tract. Currently, approved research lists the following safe dosage values :. Or, for more information regarding suggested use and other supplement facts, contact us today. All recommendations are tested or inspected as many as 15 times throughout the manufacturing process. That is why you can shop with confidence and know we take pride in helping our readers become happy through healthy living.
Matthew Poteet, Pharm. After his undergraduate training, he completed the Doctor of Pharmacy program at Mercer University Southern School of Pharmacy, graduating in Poteet has spent much of his pharmacy career on staff at two of the most prestigious academic teaching hospitals in the Southeast; Emory University in Atlanta and Vanderbilt University Medical Center in Nashville.
At these institutions he received extensive experience and training in sterile products compounding. He returned home to East Tennessee in , where he has held the position of Pharmacy Director at two sterile products pharmacies in Knoxville. Matthew lives in Knoxville with his wife, Chris. Sign up for recipes, health tips and so much more, delivered right to your inbox.
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