Outcome Measures. Will measure average pain using the Brief Pain Inventory at baseline and after 8 weeks of therapy with cyclobenzaprine. Other Outcome Measures: Percentage of Subjects Who Continue to Take Aromatase Inhibitor Therapy [ Time Frame: 24 weeks ] We will assess the number of patients who continue to take the original aromatase inhibitor medication at the 24 week timepoint, as assessed using patient self-report and medical records.
Persistence with cyclobenzaprine therapy for 24 weeks will be assessed using a medication diary. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Histologically proven stage 0-III invasive carcinoma of the breast Initiating or have been receiving a standard dose of aromatase inhibitor therapy letrozole 2. Trouble sleeping during the past week. Subjects with a history of hypothyroidism must have been on a stable dose of thyroid replacement medicine for at least 3 months prior to enrollment Treatment with steroids within 1 month Treatment with monoamine oxidase inhibitors MAO-I within 14 days of enrollment.
Concurrent treatment with bupropion, MAO inhibitors, phenothiazines including thioridazine , selegiline, tramadol, or medications known to prolong the QT interval www. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. Breast cancer Aromatase inhibitor. National Library of Medicine U. National Institutes of Health U. Flexeril has the potential to cause severe nervous system problems as well as mental problems.
This includes loss of muscle tone, disorientation, anxiety, and even psychosis. A common Flexeril side effect is drowsiness. People should avoid responsibilities that require alertness until they know how Flexeril will affect them. Some people may not experience a feeling of drowsiness while others may feel it intensely. Other common Flexeril side effects are nausea, dry mouth, and feeling dizzy.
Flexeril has antihistamines in it which can cause some of the side effects. There is also the possibility of tolerance to the drug, so patients may have to take higher doses to feel the effects. This is where Flexeril dependency can occur. The brain will become accustomed to the constant presence of cyclobenzaprine, relying on it to function properly. As a result, cyclobenzaprine dependency can occur.
Cyclobenzaprine recreational use can also increase the risk of developing Flexeril dependency and addiction. Flexeril has been found to cause liver damage if a person abuses the drug. The liver can become inflamed and swollen. A person can end up with jaundice or bile can be blocked from the liver into the intestines.
Similar to severe alcohol abuse , then, Flexeril abuse can end up causing permanent and potentially life-threatening damage to the liver and other vital internal organs. Flexeril is not a narcotic and will usually not show up on a basic 5-panel drug screen.
This is because cyclobenzaprine has a chemical structure like a tricyclic antidepressant. The 5-panel test is the general test used by employers and doctors.
It includes meth, opiate, THC, Benzodiazepine, and cocaine. Cyclobenzaprine does show up in urine tests. It has a half-life of 18 hours so it will stay in the body for about 90 hours. This means it will show up on drug tests for nearly 4 days. If a person has liver or kidney problems, the drug may remain in the body for longer.
This is because the liver will take longer to process the drug through. This is because it can give false positives on other narcotic substances. If cyclobenzaprine is taken for the 14 days that is advised, there is very little risk of Flexeril addiction.
Flexeril is considered to be a drug with abuse potential with addictive qualities. If addicts can use a stronger drug , they would choose it over Flexeril.
The dependence on cyclobenzaprine is proven by the withdrawal symptoms that occur once the medication leaves the bloodstream. Symptoms of Flexeril withdrawal include:.
There is also the possibility of becoming psychologically dependent on Flexeril because of the feelings of relaxation. And when cyclobenzaprine and alcohol, opioids, or drugs are used in combination, that risk becomes even higher.
People will abuse cyclobenzaprine to enhance the effects of alcohol or mind-altering drugs. As a result, the cyclobenzaprine high can actually end up leading to the development of addictions to other drugs as well. One of the risks of Flexeril withdrawal includes Flexeril discontinuation syndrome.
People who abuse Flexeril for years and in large amounts may develop the syndrome. The withdrawal syndrome with Flexeril is similar to when people try to stop using tricyclic antidepressants. This is often why people will be admitted into an addiction treatment clinic for Flexeril withdrawal. During cyclobenzaprine addiction treatment, the medication will be slowly tapered off by a reduction of amounts over a certain time frame.
This can help patients avoid the discomfort of withdrawing from cyclobenzaprine. Flexeril is not a narcotic. It is given to patients who are more likely to abuse opiate pain killers and is considered less risky for abuse and addiction. Regardless of the slight high, it gives to users, there is also the potential of becoming dependent on it. The slight relaxing feeling can become something that becomes a normal part of their everyday experience.
This addiction is marked by compulsive drug-seeking behaviors, even when the negative effects of these behaviors are fully recognized. However, overcoming any addiction can be an incredibly trying process. If you attempt to quit using it on your own, you put yourself at risk for an overdose. This could end up having deadly consequences. If you quit Flexeril and then go back to using, your body may not be ready for a high dose of cyclobenzaprine.
You could experience:. Sometimes people will even have a heart attack or develop seizures. Both can occur when you overdose on Flexeril. In order to quit safely, you need to opt for professional Flexeril rehab. Getting treated for your Flexeril addiction professional has so many benefits.
For one, you are able to learn from people who understand how this type of addiction works. You also get to gain insight into what caused it to occur for you in the first place. It could have happened for a number of reasons. Maybe you were depressed or anxious and Flexeril offered you a way to feel calm.
No matter what the reason is, understanding it is critical because then, the cause can be treated. At Northpoint Recovery , we know that there are challenges when recovering from an addiction.
Do you have questions about Flexeril addiction or about how you can get treated? Please contact us right away. Flexeril is a prescription muscle relaxer that may be sold under its generic name, cyclobenzaprine. It may also be sold under the brand names, Amrix and Fexmid. Flexeril is typically prescribed to people who suffer from certain types of muscle pain. It relaxes the muscles in the body by blocking the nerve impulses or pain sensations that are sent to the brain.
It may be combined with an opioid pain reliever such as Vicodin or Oxycodone for severe or chronic pain in some cases. Doctors will frequently request that their patients try other forms of treatment as well while they are taking Flexeril. Call your doctor for medical advice about side effects. There is a problem with information submitted for this request. Sign up for free, and stay up-to-date on research advancements, health tips and current health topics, like COVID, plus expert advice on managing your health.
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